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cathepsin b การใช้

ประโยคมือถือ
  • Overexpression of cathepsin B is associated with the development of malignancies.
  • They act by transactivating cathepsin B promotor activity and inducing its mRNA expression.
  • It is also an inhibitor of human cathepsin B.
  • Narlaprevir does not bind to human proteases, with the exception of cathepsin B ( 69 % inhibition ).
  • It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain.
  • The mechanism of action by which nitroxoline inhibits cathepsin B may also suggest that further research of noncovalent, noncompetitive inhibitors of cathepsin B could be warranted.
  • The mechanism of action by which nitroxoline inhibits cathepsin B may also suggest that further research of noncovalent, noncompetitive inhibitors of cathepsin B could be warranted.
  • Fleiss " et al " . ( 1998 ) report the inner mucosa contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone.
  • Nitroxoline has been shown to inhibit the enzymatic activity of cathepsin B . Cathepsin B degrades extra-cellular membrane proteins in tumor cells, allowing them to proliferate more freely, and metastasize throughout the body.
  • Nitroxoline has been shown to inhibit the enzymatic activity of cathepsin B . Cathepsin B degrades extra-cellular membrane proteins in tumor cells, allowing them to proliferate more freely, and metastasize throughout the body.
  • Cathepsin B may enhance the activity of other protease, including matrix metalloproteinase, urokinase ( serine protease urokinase plasminogen activator ), and cathepsin D, and thus it has an essential position for in the proteolysis of extracellular matrix components, intercellular communication disruption, and reduced protease inhibitor expression.
  • The " K " i ( dissociation constant ) values it demonstrates are comparable to other reversible inhibitors of cathepsin B . This indicates that it may be a candidate for further trials as an anticancer drug, especially given its history as an antimicrobial agent and its well-known pharmacokinetic profile.